Researchers have developed a blood test that detects Parkinson's disease, potentially establishing a way to help diagnose the condition before nervous system damage worsens. A new blood-based diagnostic test would be a major advancement for Parkinson's disease, which afflicts 10 million people worldwide and is the second-most common neurodegenerative disease after Alzheimer's.
Researchers have developed a blood test that detects Parkinson's disease, potentially establishing a way to help diagnose the condition before nervous system damage worsens.
As a biomarker for their diagnostic tool, Sanders and colleagues focused on DNA damage in the mitochondria. Mitochondria are factories within cells that convert raw energy into a form that powers cells. They contain their own DNA, which can undergo damage separately from the nuclear DNA that encodes most of an organism's genome.
A further analysis in cells from patients with Parkinson's disease explored whether the team's PCR-based test could determine the effectiveness of a therapy that targets the effects associated with LRRK2 mutation.
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