Researchers have developed a new type of neural implant that could restore limb function to amputees and others who have lost the use of their arms or legs. In a study carried out in rats, researchers from the University of Cambridge used the device to improve the connection between the brain and
In a study carried out in rats, researchers from the University of Cambridge used a biohybrid device to improve the connection between the brain and paralyzed limbs. The device combines flexible electronics and human stem cells – the body’s ‘reprogrammable’ master cells – to better integrate with the nerve and drive limb function. Credit: University of Cambridge
While extensive research and testing will be needed before it can be used in humans, the device is a promising development for amputees or those who have lost function of a limb or limbs. The results were reported on March 22, 2023, in the journalA huge challenge when attempting to reverse injuries that result in the loss of a limb or the loss of function of a limb is the inability of neurons to regenerate and rebuild disrupted neural circuits.
“An axon itself has a tiny voltage,” said Barone. “But once it connects with a muscle cell, which has a much higher voltage, the signal from the muscle cell is easier to extract. That’s where you can increase the sensitivity of the implant.” The cell layer also improved the function of the device, by improving resolution and allowing long-term monitoring inside a living organism. The cells survived through the 28-day experiment: the first time that cells have been shown to survive an extended experiment of this kind.
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