Pantoan Methacrylate (PAMA), a novel hydrogel or “bactogel” showed promising results in treating muscle injuries in rats.
Researchers have created a new hydrogel, using the healing power of bacteria, which can open new venues in the field of tissue engineering and cell therapy.describes a new biopolymer made of bacteria that can heal tissue. Pantoan Methacrylate , a novel hydrogel or “bactogel,” showed promising results in treating muscle injuries in rats.
Associate Professor Alireza Dolatshahi-Pirouz from DTU Health Tech said, “This combination of feats is rarely encountered in the field as the hydrogels that exist simply don’t function as well as they’re supposed to because muscle-building is mechanically demanding.”The research team from the Technical University of Denmark, led by Alireza Dolatshahi-Pirouz, capitalized on the body’s regenerative capacity using the “native bioproduction facilities” built-in bacteria.
“All the hydrogel-treated groups showed an increased number of myofibers displaying centrally located nuclei when compared to the non-treated groups,” the authors stated in the study. The role collagen plays in the development of mature muscle constructs was clear back then. Other biopolymers have emerged throughout the years as options, but “injectable hydrogels with high bioactivity and cell-infiltration capacity showed to be the most promising.”display subpar mechanical properties that do not fit the mechanically demanding milieu of musculoskeletal tissues, such as muscles,” Dolatshahi-Pirouz continues. So they “methacrylated” a bacteria-derived biomaterial.
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