Tumors often contain areas of oxygen-deficient tissue that frequently withstand conventional therapies. This is because the drugs applied in tumors require oxygen to be effective.
An international research team has developed a novel mechanism of action that works without oxygen: polymeric incorporated nanocatalysts target the tumor tissue selectively and switch off the glutathione that the cells need to survive.
The mechanism of action developed by Karges' team works without oxygen."It's a catalyst based on the element ruthenium, which oxidizes the naturally present glutathione in the cancer cells and switches it off," explains Karges. Glutathione is essential for the survival of cells and protects them from a wide range of different factors. If it ceases to be effective, the cell deteriorates.All cells of the body need and contain glutathione.
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