There are now more options for antibody-drug conjugates in metastatic breast cancer, with new treatments and combinations being explored.
CHICAGO — The landscape of antibody-drug conjugates, or ADCs, continues to grow more crowded in metastatic breast cancer . Indications are expanding, new agents are emerging, combinations with other drug classes are being tested, and many patients with this disease are now receiving more than one ADC.
Dr Giordano and his colleagues' study is the first to look at this ADC in breast cancer. EV's antibody targets the cell adhesion molecule Nectin-4. About 40% of participants were found to have PD-L1-positive tumors and, among this subgroup, there was a 4.4-month increase in median PFS and 6.0-month increase in median OS with the addition of pembrolizumab to SG, although this did not reach statistical significance. at the time of progression, thus switching the target of the ADC from HER2 to TROP2 or vice versa.
Dr Garrido-Castro's study will collect tumor samples and blood samples for the purposes of planned correlative analyses to try to better understand the mechanisms that drive response and resistance to these agents.
Metastatic Breast Carcinoma Metastatic Breast Cancer MBC Mbc Advanced BC Metastatic BC Metastatic Breast Cancer (MBC) MBC - Metastatic Breast Cancer Biologic Therapy Biologics Breast Cancer Malignant Breast Neoplasm Breast Carcinoma HER2-Low Breast Cancer HER2-Low (HER2)-Low Breast Cancer Human Epidermal Growth Factor Receptor 2 Low Brea
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