A new Review in ScienceTM looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia.
Astrocytes are abundant glial cells in the central nervous system that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intricate interactions between astrocytes, other CNS-resident cells, and CNS-infiltrating cells as well as their potential therapeutic value in the context of inflammation and neurodegeneration.O. A.
H. H. Tsai, H. Li, L. C. Fuentealba, A. V. Molofsky, R. Taveira-Marques, H. Zhuang, A. Tenney, A. T. Murnen, S. P. J. Fancy, F. Merkle, N. Kessaris, A. Alvarez-Buylla, W. D. Richardson, D. H. Rowitch, Regional astrocyte allocation regulates CNS synaptogenesis and repair. M. A. Wheeler, I. C. Clark, E. C. Tjon, Z. Li, S. E. J. Zandee, C. P. Couturier, B. R. Watson, G. Scalisi, S. Alkwai, V. Rothhammer, A. Rotem, J. A. Heyman, S. Thaploo, L. M. Sanmarco, J. Ragoussis, D. A. Weitz, K. Petrecca, J. R. Moffitt, B. Becher, J. P. Antel, A. Prat, F. J. Quintana, MAFG-driven astrocytes promote CNS inflammation.
M. Gharagozloo, M. D. Smith, J. Jin, T. Garton, M. Taylor, A. Chao, K. Meyers, M. D. Kornberg, D. J. Zack, J. Ohayon, B. A. Calabresi, D. S. Reich, C. G. Eberhart, C. A. Pardo, C. Kemper, K. A. Whartenby, P. A. Calabresi, Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation.
J. S. Sadick, M. R. O’Dea, P. Hasel, T. Dykstra, A. Faustin, S. A. Liddelow, Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease. S. F. Lau, H. Cao, A. K. Y. Fu, N. Y. Ip, Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
T. M. Sonninen, R. H. Hämäläinen, M. Koskuvi, M. Oksanen, A. Shakirzyanova, S. Wojciechowski, K. Puttonen, N. Naumenko, G. Goldsteins, N. Laham-Karam, M. Lehtonen, P. Tavi, J. Koistinaho, Š. Lehtonen, Metabolic alterations in Parkinson's disease astrocytes. M. A. Anderson, J. E. Burda, Y. Ren, Y. Ao, T. M. O’Shea, R. Kawaguchi, G. Coppola, B. S. Khakh, T. J. Deming, M. V. Sofroniew, Astrocyte scar formation aids central nervous system axon regeneration.
A. Zeisel, H. Hochgerner, P. Lönnerberg, A. Johnsson, F. Memic, J. van der Zwan, M. Häring, E. Braun, L. E. Borm, G. la Manno, S. Codeluppi, A. Furlan, K. Lee, N. Skene, K. D. Harris, J. Hjerling-Leffler, E. Arenas, P. Ernfors, U. Marklund, S. Linnarsson, Molecular architecture of the mouse nervous system.
I. C. Clark, C. Gutiérrez-Vázquez, M. A. Wheeler, Z. Li, V. Rothhammer, M. Linnerbauer, L. M. Sanmarco, L. Guo, M. Blain, S. E. J. Zandee, C. C. Chao, K. V. Batterman, M. Schwabenland, P. Lotfy, A. Tejeda-Velarde, P. Hewson, C. Manganeli Polonio, M. W. Shultis, Y. Salem, E. C. Tjon, P. H. Fonseca-Castro, D. M. Borucki, K. Alves de Lima, A. Plasencia, A. R. Abate, D. L. Rosene, K. J. Hodgetts, M. Prinz, J. P. Antel, A. Prat, F. J.
L. Hösli, M. Zuend, G. Bredell, H. S. Zanker, C. E. P. de Oliveira, A. S. Saab, B. Weber, Direct vascular contact is a hallmark of cerebral astrocytes. K. S. Christopherson, E. M. Ullian, C. C. A. Stokes, C. E. Mullowney, J. W. Hell, A. Agah, J. Lawler, D. F. Mosher, P. Bornstein, B. A. Barres, Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.
J. H. Lee, J. Y. Kim, S. Noh, H. Lee, S. Y. Lee, J. Y. Mun, H. Park, W. S. Chung, Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis. M. Merlini, E. P. Meyer, A. Ulmann-Schuler, R. M. Nitsch, Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice.
K. A. Guttenplan, M. K. Weigel, P. Prakash, P. R. Wijewardhane, P. Hasel, U. Rufen-Blanchette, A. E. Münch, J. A. Blum, J. Fine, M. C. Neal, K. D. Bruce, A. D. Gitler, G. Chopra, S. A. Liddelow, B. A. Barres, Neurotoxic reactive astrocytes induce cell death via saturated lipids. H. S. Domingues, C. C. Portugal, R. Socodato, J. B. Relvas, Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair.
J. S. Graves, K. M. Krysko, L. H. Hua, M. Absinta, R. J. M. Franklin, B. M. Segal, Ageing and multiple sclerosis. L. Mayo, S. A. Trauger, M. Blain, M. Nadeau, B. Patel, J. I. Alvarez, I. D. Mascanfroni, A. Yeste, P. Kivisäkk, K. Kallas, B. Ellezam, R. Bakshi, A. Prat, J. P. Antel, H. L. Weiner, F. J. Quintana, Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
C. P. Profaci, R. N. Munji, R. S. Pulido, R. Daneman, The blood-brain barrier in health and disease: Important unanswered questions. J. F. Yang, H. Q. Tao, Y. M. Liu, X. X. Zhan, Y. Liu, X. Y. Wang, J. H. Wang, L. L. Mu, L. L. Yang, Z. M. Gao, Q. F. Kong, G. Y. Wang, J. H. Han, B. Sun, H. L. Li, Characterization of the interaction between astrocytes and encephalitogenic lymphocytes during the development of experimental autoimmune encephalitomyelitis in mice.
M. Li, Z. Li, Y. Yao, W. N. Jin, K. Wood, Q. Liu, F. D. Shi, J. Hao, Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. A. Cornet, E. Bettelli, M. Oukka, C. Cambouris, V. Avellana-Adalid, K. Kosmatopoulos, R. S. Liblau, Role of astrocytes in antigen presentation and naive T-cell activation.
R. Y. Kim, A. S. Hoffman, N. Itoh, Y. Ao, R. Spence, M. V. Sofroniew, R. R. Voskuhl, Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis. Y. M. Khaw, A. Tierney, C. Cunningham, K. Soto-Díaz, E. Kang, A. J. Steelman, M. Inoue, Astrocytes lure CXCR2-expressing CD4R. Brambilla, T. Persaud, X. Hu, S. Karmally, V. I. Shestopalov, G. Dvoriantchikova, D. Ivanov, L. Nathanson, S. R. Barnum, J. R. Bethea, Transgenic inhibition of astroglial NF-κB improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation.
Y. Yan, X. Ding, K. Li, B. Ciric, S. Wu, H. Xu, B. Gran, A. Rostami, G. X. Zhang, CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. J. E. Kenison, A. Jhaveri, Z. Li, N. Khadse, E. Tjon, S. Tezza, D. Nowakowska, A. Plasencia, V. P. Stanton Jr., D. H. Sherr, F. J. Quintana, Tolerogenic nanoparticles suppress central nervous system inflammation.
B. M. Scott, C. Gutiérrez-Vázquez, L. M. Sanmarco, J. A. da Silva Pereira, Z. Li, A. Plasencia, P. Hewson, L. M. Cox, M. O’Brien, S. K. Chen, P. M. Moraes-Vieira, B. S. W. Chang, S. G. Peisajovich, F. J. Quintana, Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease.
S. P. Gadani, J. T. Walsh, I. Smirnov, J. Zheng, J. Kipnis, The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. M. Krumbholz, D. Theil, T. Derfuss, A. Rosenwald, F. Schrader, C. M. Monoranu, S. L. Kalled, D. M. Hess, B. Serafini, F. Aloisi, H. Wekerle, R. Hohlfeld, E. Meinl, BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma.
D. C. Hargreaves, P. L. Hyman, T. T. Lu, V. N. Ngo, A. Bidgol, G. Suzuki, Y. R. Zou, D. R. Littman, J. G. Cyster, A coordinated change in chemokine responsiveness guides plasma cell movements. L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. T. Burton, J. Wahis, J. Verhaert, S. H. K. Tareen, C. P. Roca, K. Singh, C. E. Whyte, A. Kerstens, Z. Callaerts-Vegh, S. Poovathingal, T. Prezzemolo, K. Wierda, A. Dashwood, J. Xie, E. van Wonterghem, E. Creemers, M. Aloulou, W. Gsell, O. Abiega, S. Munck, R. E. Vandenbroucke, A. Bronckaers, R. Lemmens, B. de Strooper, L. van den Bosch, U.
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