Three potential suitors have emerged for a Kyrie Irving trade, sources tell ShamsCharania: ◽️ Dallas Mavericks ◽️ Los Angeles Lakers ◽️ Phoenix Suns
The Nets have gone 29-15 under Nash’s replacement Jacque Vaughn and sit in fourth place in the East entering Friday despite losing seven of their last 11 withoutIt wouldn’t be a trade deadline without a Nets star wanting out of town. Irving’s request puts uncertainty around the rest of the Nets’ season, one that appeared good enough to make the second round of the playoffs, if not beyond.
The Nets have stuck with Irving throughout all of his headlines in Brooklyn. Is this the one that changes that? —I just wonder who is going to trade for him. On one hand, Irving poses the least amount of risk for a team to take on while he’s on an expiring contract. But would an executive want to add him to the mix if his own team has a good thing going? Nothing is certain with Irving. Trading for him, even at a reduced asking price could still blow up easily.
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Efficacy, safety, and tolerability of antidepressants for pain in adults: overview of systematic reviewsObjective To provide a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for pain according to condition. Design Overview of systematic reviews. Data sources PubMed, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials from inception to 20 June 2022. Eligibility criteria for selecting studies Systematic reviews comparing any antidepressant with placebo for any pain condition in adults. Data extraction and synthesis Two reviewers independently extracted data. The main outcome measure was pain; for headache disorders it was frequency of headaches. Continuous pain outcomes were converted into a scale of 0 (no pain) to 100 (worst pain) and were presented as mean differences (95% confidence intervals). Dichotomous outcomes were presented as risk ratios (95% confidence intervals). Data were extracted from the time point closest to the end of treatment. When end of treatment was too variable across trials in a review, data were extracted from the outcome or time point with the largest number of trials and participants. Secondary outcomes were safety and tolerability (withdrawals because of adverse events). Findings were classified from each comparison as efficacious, not efficacious, or inconclusive. Certainty of evidence was assessed with the grading of recommendations assessment, development, and evaluation framework. Results 26 reviews (156 unique trials and |25 000 participants) were included. These reviews reported on the efficacy of eight antidepressant classes covering 22 pain conditions (42 distinct comparisons). No review provided high certainty evidence on the efficacy of antidepressants for pain for any condition. 11 comparisons (nine conditions) were found where antidepressants were efficacious, four with moderate certainty evidence: serotonin-norepinephrine reuptake inhibitors (SNRIs) for back pain (mean difference −5.3, 95% confidence interval −7.3 to −3.3), postoperative pain (−7.3, −12.9 to −1.7), neurop
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