Researchers discovered that nerve cells conserve energy through precise control of mRNA and protein location and quantity. This energy-saving program varies based on molecule properties like length and lifespan, ensuring efficient protein synthesis and transport to synapses.
Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers found that the neuronal energy conservation program determines the location and number of messenger RNA and proteins, and differs depending on the length, longevity and other properties of the respective molecule.
Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers from the University Hospital Bonn and the University of Bonn as well as the University Medical Center Göttingen found that the neuronal energy conservation program determines the location and number of messenger RNA and proteins, and differs depending on the length, longevity and other properties of the respective molecule. The work has now been published in the journalWe have all experienced the need to save energy in recent years. To do this, we all had to come up with strategies to save energy while still meet our most important needs."Our nerve cells are facing a similar dilemma: They have to supply their synapses, i.e. their contact points with other neurons, but also organize their protein synthesis in such a way that they don't produce too much or too little proteins. At the same time, they have to transport the proteins over long distances to the synapses and also pay attention to their energy budget. How do they manage this?" asked the research team led by corresponding author Prof. Prof. Tatjana Tchumatchenko, research group leader at the Institute for Experimental Epileptology and Cognition Researchat the UKB and member of the Transdisciplinary Research Areas "Life and Health" and"Modeling" at the University of Bonn.Despite its relatively small size, the brain consumes around 20 percent of the body's total energy. As with all cells, neuronal functions are subject to strict energy constraints, which are particularly pronounced in the brain due to its high energy requirements. The research team was able to show that the synthesis and degradation of all neuronal molecules represents a particularly high cellular energy expenditure and therefore requires energy-saving measures. All cells, including neurons, require proteins to function properly. These are produced through a process known as gene expression, in which the relevant information is copied from a gene into messenger RNA . The mature mRNA is then translated into the required protein. Thanks to advances in biochemistry and microscopy, it is now possible to precisely map the location of individual mRNA copies and the corresponding proteins in cells and quantify the number for thousands of mRNA and protein species. For the first time, this enables researchers to study complex organizational principles that control spatial gene expression patterns and apply across all types of molecules. The research team combined experimental data from more than ten large-scale mRNA and proteomics screens involving tens of thousands of molecular species."We found that the drive to conserve energy determines mRNA and protein number and location, affecting each molecular species differently depending on the length, lifetime and other properties of the molecule," explains first author Cornelius Bergmann, a PhD student of the University Bonn at the Institute of Experimental Epileptology and Cognition Research at the UKB. The results show that the energetic costs for synthesis, transport and degradation of molecules, their spatial localization and the total number are limited to energy-efficient solutions."If certain short-lived proteins were synthesized in the cell body, a large proportion of them would not arrive alive at the synapses due to the long travel time," adds Prof. Tchumatchenko."This would be a waste of energy on proteins that cannot fulfill their task." The model calculations in the present study show that proteins are therefore preferably synthesized in the branched, tapering extensions of a nerve cell, the so-called dendrites, if the energy loss"on the way" from the cell body to the synapses is greater than the energy required to transport the mRNA into the dendrites.However, the research team's findings go beyond energy conservation."Our results shed light on the organizational principles of gene expression in cells that act across different molecular species and go beyond individual regulatory mechanisms," says co-author Prof. Silvio Rizzoli, Director of the Department of Neuro- and Sensory Physiology at the University Medical Center Göttingen, spokesperson of the Center for Biostructural Imaging of Neurodegeneration and member of the Cluster of Excellence"Multiscale Bioimaging: from molecular machines to networks of excitable cells" . The most surprising result for the research team was that the physical properties of proteins, such as length or lifetime, and not their specific function, have such a strong influence on the energy budget and thus on the site of their synthesis. Co-author Kanaan Mousaei, a doctoral student of the University Bonn at the Institute of Experimental Epileptology and Cognition Research at the UKB, emphasizes:"Our model offers a new perspective for correlating dozens of existing data sets from different laboratories."Nerve cells in the brain demand an enormous amount of energy to survive and maintain their connections for communicating with other nerve cells. In Alzheimer's disease, the ability to make energy is ... Dopamine is an important signalling molecule for nerve cells. Its concentration could not be precisely determined with both high spatial or temporal resolution until now. A new method has now made ... The brain is assumed to exert homeostatic functions to always keep the cellular energy status constant, this has not been proven. Researchers discovered that cortical neuronal intracellular ... Scientists studying neuronal energy metabolism found evidence the loss of an important energy regulator called AMPK in neural stem cells or glial cells called astrocytes causes neuronal death in ...Working Dogs Take a Day to Adjust to Daylight Savings Time, but Pets Are More Flexible
NEURONS ENERGY CONSERVATION PROTEINS Mrna SYNAPSE
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