Gastroesophageal cancer dynamics and drivers of clinical responses with immune checkpoint inhibitors (ICI) remain poorly understood. Potential synergistic activity of dual programmed cell death protein 1 (PD-1) and lymphocyte-activation gene 3 (LAG-3) inhibition may help improve immunotherapy responses for these tumors.
Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses
Feasibility was assessed through the proportion of eligible patients who proceeded to surgery without substantial treatment-related delay; the latter was defined as more than 11 weeks from completion of chemoradiation. A Bayesian continuous monitoring plan was used to monitor if the proportion was evidently greater than 75% . Of the patients eligible for surgery after completion of neoadjuvant therapy, one patient declined surgery and another patient underwent resection at 11.
Known positive history or positive test for human immunodeficiency virus or acquired immunodeficiency syndrome.Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2 or anti-LAG-3 antibody . Somatic variants were identified across the targeted regions using VariantDx, and variant origin was determined using a tumor-agnostic WBC-informed approach. Germline and CH variants were filtered out using matched WBC DNA sequencing.
This study was funded by Bristol Myers Squibb. The funder had no role in study design, data collection and analysis and decision to publish.
Representative radiotherapy plan of patient CGES26 who experienced adrenal insufficiency toxicity. Radiotherapy DICOMs are shown in representative axial, sagittal and coronal slices.Dose volume histogram of target and normal structures; all target and normal structure dose objectives met protocol-specified markers of plan quality, which mirror national guidelines.DVH of right, left and combined adrenal glands; listed below the DVH are dose statistics for adrenal glands.
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