Nature’s Anti-Aging Blueprint: How Naked Mole-Rats Are Redefining What We Know About Aging

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Nature’s Anti-Aging Blueprint: How Naked Mole-Rats Are Redefining What We Know About Aging
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Science, Space and Technology News 2023

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Cellular senescence is characterized by the irreversible arrest of cell division, which progresses with age. Senescent cells are less prone to cell death and accumulate in the tissues as they age, promoting chronic inflammation and compromising the function of these tissues. While cellular senescence plays an important role in aging, little is known about its function in NMRs.

Through further experiments, the researchers observed that there was an accumulation of serotonin in the non-senescent NMR fibroblasts, but not in the mouse fibroblasts. Upon senescence induction, in NMR cells, serotonin was metabolized by monoamine oxidase and converted to 5-hydroxyindole aceticAn infographic depicting a unique “natural senolytic” or natural senescent cell removal mechanism identified by Japanese researchers, in naked mole-rats, the longest-lived rodent species.

To confirm if a similar mechanism was also prevalent in vivo, the team induced cellular senescence in the lungs of mice and NMRs using bleomycin . They observed that cell death, likely due to an acute response to DNA damage, initially increased on day 2 in both mouse and NMR lung cells. However, after an initial rise on day 2, a fall in cell death was observed and by day 21, cell death had increased again, only in NMR lung cells.

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