The August issue is live On the cover, an artist’s impression of a protein translocating through a nanopore. Yu et al. identify conditions allowing proteins to translocate through a nanopore when driven by an electroosmotic effect
The collection of RNAs in a cell reflects its identity and behavior. Although probing these RNAs in the present is commonplace, peering into the past remains challenging. We developed TIGER to record selected RNAs at the single-cell level, enabling us to connect the past with the present.
Sequencing of proteins is a technically difficult task that typically requires digestion into short peptides before detection and identification. We developed a digestion-free method to chemically unfold and ‘scan’ full-length proteins through a nanopore, producing electrical fingerprints unique to individual protein molecules that are useful in their identification.
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