A retrospective study investigated the positive predictive value (PPV) of 17 myositis antibodies for diagnosing myositis and related conditions. The study found that greater diagnostic accuracy is associated with stronger antibody band intensities and the simultaneous presence of two or more myositis antibodies. Anti-HMGCR antibodies demonstrated the highest PPV for myositis diagnosis at 94%.
The positive predictive value of myositis antibodies for diagnosing myositis and its related conditions differs by individual antibody type. Greater diagnostic accuracy is associated with stronger antibody band intensities and the simultaneous presence of two or more myositis antibodies.Researchers conducted this retrospective study to assess the PPVs of 17 myositis antibodies for diagnosing myositis and other myositis-related conditions .
Clinical diagnoses of myositis and other myositis-related conditions were extracted from the Care Register for Health Care between January 2013 and June 2022. Antisynthetase antibodies exhibited PPVs of 25%-47% for the diagnosis of ILD, and the diagnosis of CTDs and malignancies was common in individuals who tested positive for anti-Ro52 and anti-TIF1-γ antibodies, respectively.
MYOSITIS ANTIBODIES DIAGNOSIS IMMUNE SYSTEM LABORATORY TESTS
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