Nature research paper: Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful against COVID-19, there is a concern that the same could occur for nirmatrelvir.
Sho Iketani, Hiroshi Mohri, Maria I. Luck, Yicheng Guo, Zizhang Sheng, Stephen P. Goff, Yosef Sabo & David D. Ho Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Sho Iketani, Hiroshi Mohri, Maria I. Luck, Medini K. Annavajhala, Yicheng Guo, Zizhang Sheng, Anne-Catrin Uhlemann, Yosef Sabo & David D. Ho
Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USAMedical Scientist Training Program, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADepartment of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USAShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech...
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