In Colorado, it's often associated with the death of Elijah McClain, but ketamine can work for treatment-resistant depression — however, there are still many unknowns.
Though it’s perhaps most associated in Colorado with the death of, ketamine is a medication that can work for people whose depression isn’t helped by other treatments — but much remains unknown, and it’s up to the patient to figure out if a provider is a good choice.
No agency in Colorado oversees ketamine infusion clinics, and the U.S. Food and Drug Administration doesn’t have jurisdiction over “off-label” prescribing — giving patients an approved drug for an unapproved use. The state boards that license doctors and nurses oversee people who work in the clinics in the same way that they do any doctor or nurse, and could take action if they received complaints that patients were being harmed.
reported their symptom severity had been cut roughly in half one day after their infusion. That study, like most others, tested ketamine in people who hadn’t been helped by at least two types of antidepressants. Most of the studies of ketamine tried a dose of no more than one-half milligram for every kilogram of a person’s weight, given four to six times over two to three weeks. Langston said most of her patients receive that dose, though occasionally it makes sense to go lower or somewhat higher. They continuously monitor patients’ heart rates and blood oxygen levels, and periodically check their blood pressure during the infusion, she said.
“When the FDA granted the approval, that was part of the package. That had some unintended consequences,” he said.
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