With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently.
Mar 18 2024Deutsches Zentrum fuer Diabetesforschung DZD Although it is known that the oral antidiabetic agent can cross the placental barrier, the impacts on the brain development of the child are largely unknown. An interdisciplinary research team from the German Institute of Human Nutrition Potsdam-Rehbrücke have now been able to demonstrate in a mouse model that although metformin has positive effects in pregnant animals, it does not in the offspring.
Long-term effect of metformin on offspring is unclear For several years, the placenta-crossing oral antidiabetic agent metformin has been increasingly gaining importance as an alternative to insulin administration when lifestyle changes show no success during the treatment of gestational diabetes. However, there are currently only a few studies on the long-term effects of metformin on the health of offspring.
Treatment involved insulin, metformin, or a placebo, whereby the dosage was based on standard human treatments. The research team collected data on the body weight of the mice, analyzed various metabolic parameters and hormones, and examined molecular signaling pathways in the hypothalamus.
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