Scientists mapped a neural circuit that associates an unfamiliar flavor with food poisoning symptoms in mice.
Food poisoning isn’t an experience you’re likely to forget — and now, scientists know why.“We’ve all experienced food poisoning at some point … And not only is it terrible in the moment, but it leads us to not eat those foods again,” says Christopher Zimmerman of Princeton University.
Researchers knew that a brain region called the amygdala represents flavors and decides whether or not they’re gross. Palmiter’s groupthat the gut tells the brain it’s feeling icky by activating specific “alarm” neurons, called CGRP neurons. “They respond to everything that’s bad,” Palmiter says. The team had mice drink grape Kool-Aid and, 30 minutes later, injected the rodents with lithium chloride to make them ill. Two days later, they gave the mice grape Kool-Aid again. The team ran many variations on this simple experiment and peeked inside the mice’s brains at each step. In some experiments, the researchers euthanized mice and made their brains transparent to image them in 3-D.
Food Poisoning Mouse Mouse Brains
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