The TASTE trial adds to a string of previous trials showing non-inferiority of tenecteplase to alteplase. In addition, an updated meta-analysis suggests tenecteplase is superior.
The bolus thrombolytic agent, tenecteplase, narrowly failed to show non-inferiority to alteplase in the TASTE clinical trial within 4.5 hours of symptom onset selected by perfusion imaging in patients with acute ischemic stroke.
"It therefore lends considerable weight to the previous evidence showing non-inferiority of tenecteplase to alteplase, with the updated meta-analysis now suggesting superiority," he added. The primary outcome was the proportion of patients without disability at 3 months. Safety outcomes were all-cause mortality and symptomatic intracranial hemorrhage.
He pointed out that as tenecteplase is administered via a single bolus injection, it is easier and quicker to administer than alteplase, which is given as a bolus plus an infusion, thus saving time in the urgent treatment of patients with acute stroke.
Cerebrovascular Accident CVA - Cerebrovascular Accident Thromboembolism Meta-Analysis Ischemic Stroke Ischaemic Stroke Hospitals Perfusion Imaging Cardiovascular Imaging Cardiac Imaging CV Imaging Thrombolytic Therapy Fibrinolytics Thrombolytics Intracranial Hemorrhage Intracranial Bleeding Intracranial Haemorrhage Acute Stroke Board Certification Boards Board Recertification
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