Adding to sizeable RCT evidence that DOACs should be administered early following AF-related stroke, a weighted-risk analysis appeared to eliminate all doubt.
seemed to remove any doubt that essentially all patients with atrial fibrillation should receive a direct oral anticoagulant soon after an acute stroke , the exact same message was reinforced by a novel risk-weighted analysis of last year’s landmark trial.
Treating these events equally is a problem, said Polymeris. In particular, it does not rule out the increased risk for the most catastrophic events. In this post hoc analysis, weights were given to the specific events. With weights reflecting the relative risk for major harm, the study was able to show no potential for net increased major harm, not just reduced risk for events of any kind, for early vs late DOAC therapy within a range of 95% intervals.
In other words, this new analysis shows that the trade of an increased risk for ICH or bleeding is more than compensated by a reduced risk for thrombotic events on the basis of outcomes such as disability or death. Using a formula from published methodology and adjusted for variables such as age, severity as measured with the National Institutes of Health Stroke Scale, and infarct size, the events were weighted for the risk they posed. For example, while ischemic events were given a value of 1.0, extracranial bleeding, a lower risk event, was given a weight of 0.7, but ICH, often the most feared complication, was weighted at 1.5.
Though the current guidelines regarding early use of DOACs have been mixed, the ELAN post hoc analysis, along with the new data from OPTIMAS and the CATALYST meta-analysis, establish early DOAC as a standard of care for most patients with an AF-related acute stroke, according to Polymeris.
Cerebrovascular Accident CVA - Cerebrovascular Accident Thromboembolism Atrial Fibrillation AF Afib A-Fib Afib Afib Atrial Fib Atrial Fibrillation (AF) Atrial Fibrillation (A-Fib) AF - Atrial Fibrillation Acute Stroke Meta-Analysis Intracranial Hemorrhage Intracranial Bleeding Intracranial Haemorrhage Anticoagulation Therapy Anticoagulant Anticoagulation
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
How early support and systematic change can help close STEM gender gapDr Kath Mackay is Chief Scientific Officer for Bruntwood SciTech and Managing Director of its Alderley Park campus, the UK’s largest single site life science innovation campus. Her responsibilities include stimulating new business ventures and managing further development of the campus.
Read more »
Early-balloting skeptic Kari Lake explains the turnaround that led to her Early Voting Bus TourSpending on political advertisements is expected to exceed $12B this year.
Read more »
OPINION: Support legislators who support our schoolsOur schools cannot function with hundreds of teacher vacancies and far too many overcrowded classrooms with 30, 35 and even 40 or more kids.
Read more »
How many Republicans support Harris and how many Democrats support Trump?Political News and Conservative Analysis About Congress, the President, and the Federal Government
Read more »
Mariah Carey Starts Christmas Season Early by Claiming It’s Too Early to Start Christmas SeasonMariah Carey dropped a cheeky video proclaiming that early October was still a bit too early to start the 2024 Christmas season.
Read more »
How early is too early to prep for Thanksgiving?Cranberries are considered a staple of holiday dinners.
Read more »