Monovalent mRNA COVID-19 vaccines provide durable protection against critical outcomes COVID19vaccine mRNAvaccine COVID19prevention IVYnetwork publichealth CDC infectiousdiseases immunization healthresearch healthscience CDCMMWR
By Neha MathurMay 2 2023 In a recent Morbidity and Mortality Weekly Report published on the United States Center for Disease Control and Prevention website, researchers evaluated the durability of protection conferred by monovalent messenger ribonucleic acid coronavirus disease 2019 vaccines against invasive mechanical ventilation and in-hospital death during the period of the predominance of Omicron, i.e., between February 1, 2022, and January 31, 2023.
Since the beginning of the pandemic, over 1.13 million COVID-19–related deaths have occurred in the United States, with most among patients aged ≥65 years. Authorities recommended a bivalent mRNA booster for all individuals who had completed a primary COVID-19 vaccination series from September 1, 2022, onward and were at a higher risk of progression to severe disease. However, bivalent vaccination uptake remained low among adults aged ≥18 years, i.e.
They collected demographic and clinical patient data through electronic health record review, or patient/proxy interview, including IMV receipt and in-hospital death within 28 days of hospital admission. Study findings The number of enrollees with IMV or in-hospital mortality in the IVY Network between February 1, 2022, and January 31, 2023, was 6,354; however, the final analysis sample set had only 70% of 6354, i.e., 4,421 individuals, of which 362 were cases, and 4,059 were controls. The average age of all included patients was 64 years. Notably, ~91% of COVID-19 patients had one or more persistent health issues, and 20% had experienced COVID-19 at least once.
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