A research team proposes a method to assess cancer patients for their likelihood to either respond to treatment or relapse.
Researchers from Iwate Medical University and Tohoku University have revealed that it is possible to predict cancer relapse and treatment response by measuring circulating tumor DNA , in tandem with data from comprehensive genomic profiling .
The research team proposed that patients who underwent CGP could undergo ctDNA monitoring by using digital PCR . The OTS-Assay was originally developed at Iwate Medical University, and has been clinically validated for a number of different cancers. Strengthening our knowledge and further testing the validity of this system is crucial, so that it can potentially become more commonplace in clinical practice.
The clinical validity of the OTS-Assay was evaluated for"early relapse prediction,""treatment response evaluation," and"no relapse/regrowth corroboration." Monitoring of ctDNA by dPCR was performed in 11 patients. Overall, 10 of 11 patients achieved at least one of the following validated outcomes:"early relapse prediction,""treatment response evaluation," and"no relapse/regrowth corroboration.
New findings may lead to relapse-free treatment for a sizeable subgroup of lung cancer patients. In a study in mice, scientists have identified a biomarker that may help physicians select lung cancer ...
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