This study discusses the different genotypes of HEV and their transmission methods, as well as the global impact of HEV infections. It also highlights the development of hepatitis E vaccines and the need for further research on their effectiveness.
. Molecular studies of HEV strains have identified four main genotypes. Genotypes 1 and 2 are limited to humans and are transmitted through contaminated water in resource-limited countries, mainly in Asia. Genotypes 3 and 4 are zoonotic, causing sporadic indigenous hepatitis E in nearly all countries.
Follow-up occurred every 3 months. Participants with hepatitis symptoms for 3 days or more underwent alanine aminotransferase concentration measurement. Patients with ALT concentrations ≥ 2.5 times the upper limit of normal were considered to have acute hepatitis.
In the subgroups evaluated for immunogenicity persistence, among those who were initially seronegative and received three doses of hepatitis E vaccine, 254 out of 291 vaccinated participants in Qingdao after 8.5 years and 1270 out of 1740 vaccinated participants in Anfeng after 7.5 years maintained detectable antibody concentrations.
HEV Genotypes Transmission Vaccines Clinical Trial China
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