The molecular pathways involved in antiviral defenses and counter-defenses in host-pathogen systems remain unclear. Researchers have used Neurospora crassa as a model organism to explore how RNA editing influences fungal antiviral responses.
They identified two neighboring genes -- an RNA-editing enzyme and a transcription factor -- that regulate virus-induced gene expression. Their findings show how the old-zao module controls both asymptomatic and symptomatic infections, providing new insight into conserved antiviral mechanisms in fungi.
In this context, a research team from Japan, led by Associate Professor Shinji Honda from The Faculty of Medical Sciences, University of Fukui, Japan, and Professor Nobuhiro Suzuki from the Institute of Plant Science and Resources, Okayama University, set out to solve this mystery. They used their recently established fungal virology system in Neurospora crassa to unveil the genes and pathways involved in symptom induction after viral infection.
The team next identified which genomic locations are targeted by the products of old-1 and old-2- OLD-1 and OLD-2. The target locations were approximately 2 kb upstream from old-1/2 in the genome, where it modifies the stop codon of the target transcripts to continue translation and form a full protein with zinc finger domains. These neighboring regions of old-1/2 in the genome were named zao-1/2.
New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime ...
Virology Microbes And More Genetics Earth Science Geochemistry Geography Geoengineering
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Cities Contribute to Asthma, Researchers ArgueDirty, crowded urban environments can significantly increase a person's risk of developing asthma, a new study says.
Read more »
Researchers make breakthrough in semiconductor technology set to supercharge 6G deliverySelf-driving cars which eliminate traffic jams, getting a healthcare diagnosis instantly without leaving your home, or feeling the touch of loved ones based across the continent may sound like the stuff of science fiction.
Read more »
Beyond hormones: Researchers define X and Y chromosome contributions to heightA new study provides new insight into height differences between adult men and women, demonstrating that Y chromosome genes contribute more to height than their X chromosome counterparts.
Read more »
As Trump cuts science budgets, some researchers are looking abroadIt’s not clear how many scientists will find work in another country, where salaries are generally lower.
Read more »
Researchers Stumble Over World’s Largest Known Tsunami-Transported RockA boulder weighing almost 1,200 tons is one of the largest known wave-transported rocks in the world, providing new insights into the Pacific's risk of tsunamis.
Read more »
Researchers take AI to 'kindergarten' in order to learn more complex tasksWe need to learn our letters before we can learn to read and our numbers before we can learn how to add and subtract. The same principles are true with AI, a team of scientists has shown through laboratory experiments and computational modeling.
Read more »