A team of surgeons successfully transplanted genetically engineered pig hearts into two recently deceased people whose bodies were being maintained on ventilators – not in the hope of restoring life, but as a proof-of-concept experiment.
July 12, 2022 -- A team of surgeons successfully transplanted genetically engineered pig hearts into two recently deceased people whose bodies were being maintained on– not in the hope of restoring life, but as a proof-of-concept experiment in what’s known as xenotransplantation.
Through 72 hours of monitoring after the transplant “we evaluated the heart for functionality and the heart function was completely normal,” he said. Alex Reyentovich, MD, medical director of heart transplantation NYU Langone said that “there are 6 million individuals within the United States. About 100,000 of those individuals have end-stage heart failure, and we only do about 3,500 heart transplants a year in the United States, so we have a tremendous deficiency in organs, and there are many people dying waiting for a heart.
The hearts were taken from pigs genetically modified to prevent rejection – including a gene for a growth hormone that would otherwise cause the heart to continue to expand in the recipient’s chest – and with the addition human genes to protect other functions.The organ recipients were recently deceased patients who had expressed the clear wish to be organ donors but whose organs were for clinical reasons unusable for transplant.
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