CHICAGO: A series of studies in mice of Moderna's COVID-19 vaccine lent some assurance that it may not increase the risk of more severe disease, ...
CHICAGO: A series of studies in mice of Moderna's COVID-19 vaccine lent some assurance that it may not increase the risk of more severe disease, and that one dose may provide protection against the novel coronavirus, according to preliminary data released on Friday .
"This is the barest beginning of preliminary information," said Dr Gregory Poland, an immunologist and vaccine researcher at the Mayo Clinic who has seen the paper, which has yet to undergo peer-review.AdvertisementThe authors said they have submitted the work to a top-tier journal. Moderna's vaccine is in mid-stage testing in healthy volunteers. Moderna said on Thursday it plans to begin final-stage trials enrolling 30,000 people in July.
"Sub-protective doses did not prime mice for enhanced immunopathology following ," Dr Barney Graham of the Vaccine Research Center at NIAID and colleagues wrote in the manuscript, posted on the bioRxiv website. They noted the mice that received just one dose before exposure to the virus seven weeks later were"completely protected against lung viral replication," suggesting a single vaccination prevented the virus from replicating in the lungs.
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