Two specialists are impressed by the preliminary findings of a randomized trial in newly diagnosed patients, but another is critical.
Early use of mycophenolate mofetil , a drug used to dampen the immune system in organ transplant recipients, may reduce the risk for severe flares in patients with newly diagnosed systemic lupus erythematosus , according to results from a randomized, open-label, observer-blinded clinical trial.
The rates of mild to moderate flares were similar between the control and intervention groups . This finding is surprising, said Judith A. James, MD, PhD, of the University of Oklahoma Health Sciences Center in Oklahoma City."It may be that mild flares have a different mechanism or are caused by noninflammatory endotypes that don't respond to MMF."
A total of 12 patients in the MMF group discontinued the intervention for various reasons, and six were lost to follow-up. In the control group, 20 discontinued the intervention and two were lost to follow-up. However, all 130 patients in the trial were included in the primary and secondary outcome analyses.
SLE - Systemic Lupus Erythematosus Systemic Lupus Erythaematosus SLE Lupus Lupus Nephritis Nephritis Biologic Therapy Biologics Glucocorticosteroids Glucocorticoid Therapy Glucocorticoid Transplantation Of An Organ Organ Transplantation Organ Transplant Pregnancy Pregnant Birth Birth Defect Congenital Physical Anomaly Contraception Birth Control
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