Gulf War illness caused by mitochondrialdysfunction, not inflammation ucsandiego SciReports
at the UCSD Altman Clinical and Translational Research Institute with a nurse experienced in assisting in the biopsy procedure. A single muscle biopsy was performed for each participant, and all mitochondrial assessments were conducted on the resulting sample. No more than one biopsy was performed on a given day. Participants were instructed not to take blood thinning agents for 7 days prior to the procedure. Participants were prepped for the procedure using the Universal Protocol Checklist.
As per the Introduction, based on preliminary analyses, four indices of mitochondrial function are highlighted in this study. CI&CII&FAOCI/CIIOXPHOS refers to assessment of that aspect of mitochondrial function determined by using fatty acids as the fuel source with complex I and II substrates malate, glutamate, pyruvate, succinate and adenosine diphosphate ADP to drive respiration.
, examining univariable prediction by the chosen mitochondrial marker and hsCRP, then in joint analysis.Study power: The originally proposed sample size of 54 provided 80% power with two-sided alpha of 0.05 to detect a difference between cases and controls of 0.4 standard deviations.
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