Science, Space and Technology News 2023
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While the researchers’ main focus is on diabetes treatment, they say that this kind of device could also be adapted to treat other diseases that require repeated delivery of therapeutic proteins. “The vast majority of diabetics that are insulin-dependent are injecting themselves with insulin, and doing their very best, but they do not have healthy blood sugar levels,” Anderson says. “If you look at their blood sugar levels, even for people that are very dedicated to being careful, they just can’t match what a living pancreas can do.”
This photo shows the cathode side of fully assembled device, with a United States quarter-dollar coin for scale. Credit: Courtesy of Claudia Liu and Dr. Siddharth Krishnan, MIT/Boston Children’s HospitalAnother possibility, which could prevent the need for immunosuppressive drugs, is to encapsulate the transplanted cells within a flexible device that protects the cells from the immune system. However, finding a reliable oxygen supply for these encapsulated cells has proven challenging.
A significant advantage of this approach is that it does not require any wires or batteries. Splitting this water vapor requires a small voltage , which is generated using a phenomenon known as resonant inductive coupling. A tuned magnetic coil located outside the body transmits power to a small, flexible antenna within the device, allowing for wireless power transfer. It does require an external coil, which the researchers anticipate could be worn as a patch on the patient’s skin.
This approach could also be used to deliver cells that produce other types of therapeutic proteins that need to be given over long periods of time. In this study, the researchers showed that the device could also keep alive cells that produce erythropoietin, a protein that stimulates red blood cell production.“We’re optimistic that it will be possible to make living medical devices that can reside in the body and produce drugs as needed,” Anderson says.
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