MIT scientists have developed implantable microparticles offering a dual-action cancer treatment, combining targeted phototherapy and chemotherapy.
Patients with late-stage cancer often have to endure multiple rounds of different types of treatment, which can cause unwanted side effects and may not always help.
In a mice study, the researchers showed that this therapy eliminated tumors in most animals and significantly prolonged their survival.Patients with advanced tumors usually undergo a combination of treatments, including chemotherapy, surgery, and radiation. They decided to use an inorganic material called molybdenum sulfide as the phototherapeutic agent. This material converts laser light to heat very efficiently, so low-powered lasers can be used.
To optimize the treatment protocol, the researchers used machine-learning algorithms to determine the phototherapeutic agent’s laser power, irradiation time, and concentration, leading to the best outcomes.During that time, the particles are heated to about 50 degrees Celsius, which is hot enough to kill cancer tumor cells.The researchers tested the microparticle treatment in mice that were injected with an aggressive type of cancer cells from triple-negative breast tumors.
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