Discover how nanoparticle metal-organic frameworks act as efficient carriers and adjuvants, enhancing immune responses at lower doses.
Vaccines are one of the best scientific discoveries because they prevent the incidence of some of the deadliest diseases. The medical field has been using them to prevent smallpox, tuberculosis, and even cancer. A recent study shows that there is a possibility of a nanoparticle improving vaccine delivery and efficacy. Nanoparticles are small, focused materials Vaccines are one of the best scientific discoveries because they prevent the incidence of some of the deadliest diseases.
It showcases the ability of the MOFs to deliver vaccines. They also act as adjuvants to boost the immune response at a lower dosage. They used an extensive study using murine specimens. With this, the researchers successfully encapsulated and delivered part of a SARS-CoV-2 spike protein. “Not only are we delivering the protein in a more controlled way through a nanoparticle, but the compositional structure of this particle is also acting as an adjuvant,” Jaklenec says. “We were able to achieve very specific responses to theWhile the findings are promising, the researchers acknowledge the need for further adaptation of these particles for practical vaccine use.
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