For every 1000 patients with abdominal bloating, adding blood tests to the evaluation leads to 63 extra cancer referrals and identifies three more cancer cases.
Nearly half of patients with undiagnosed cancer initially present with nonspecific symptoms, which can make early detection challenging. When a patient consults a general practitioner , part of the evaluation involves determining the likelihood of a serious underlying condition, including cancer.
Of 425,549 patients with abdominal pain, 9427 received a cancer diagnosis within 12 months. Similarly, of 52,321 patients with abdominal bloating, 1148 received a cancer diagnosis within the same period. Among men, the most common cancer sites were the colon, prostate, and pancreas, while for women, they were the colon, breast, ovaries, and pancreas.
Blood tests were conducted simultaneously in large proportions of patients: 64% of those with abdominal pain and 70% with bloating. The risk increased further if repeated tests showed consistently elevated markers but decreased if the markers returned to normal. Men over age 50 years and women over age 60 years with elevated inflammatory markers had a cancer risk that exceeded the 3% NICE threshold for urgent specialist referral. However, the sensitivity for detecting cancer was still low at 46.1% for C-reactive protein and 43.6% for erythrocyte sedimentation rate.
Colorectal Cancer (CRC) Breast Cancer Malignant Breast Neoplasm Breast Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cancer Diagnostics Malignant Pancreatic Neoplasm Pancreatic Cancer Cancer Of The Pancreas Abdominal Cancer Cancer Of The Abdomen Malignant Lesion Of The Abdomen Biologic Therapy Biologics Ovarian Cancer Malignant Ovarian Neoplasm
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