Psoriasis is one of several autoimmune diseases linked to variations in MHC-1 that may have protected our ancestors from retroviruses.
SEATTLE — The genetic vulnerability to psoriasis and related autoimmune disease s may be traceable to evolutionary pressure to resist ancient infections by retroviruses. The theory is that variations in major histocompatibility complex class 1 proteins, which play a key role in presenting pathogen-derived peptides to CD8+ T cells, may have improved the immune response against these viral scourges and thus became widespread in the human genome.
. The thought is that psoriasis may be just one of a group of autoimmune diseases that trace their roots to variations in MHC-1 and peptide processing genes. These diseases,The proposed MHC-1-opathies share several other characteristics: They affect epithelial, mucosal, or mechanically affected tissues; they involve activation of CD8+ T cells; and they are often associated with upregulation of the interleukin 23, IL-17, or tumor necrosis factor cytokines, according to Liao.
Additionally, the researchers observed that very high levels of HLA-C expression are beneficial, likely because of increased levels of antigen presentation, said Liao. These increased levels can occur because of a deletion variant, and researchers found that the same deletion variant leads to a higher risk for psoriasis.
Psoriatic Arthritis Arthropathic Psoriasis Psoriatic Arthropathy Psa Autoimmune Disease AIDS Acquired Immune Deficiency Syndrome AIDS - Acquired Immune Deficiency Syndrome HIV Infection HIV Disease HIV Genetics Receptors Tumor Genetics Tumour Genetics Human Leukocyte Antigen HLA - Human Leukocyte Antigen Antigens Iga Immunoglobulin A Natural Killer Cells NK Cells NK-Cells
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