Ner findings show how a specific nucleotide metabolite called GTP controls responses to radiation and chemotherapy in an unexpected way.
Researchers have figured out how a specific metabolite controls the activity of DNA repair and how sensitive tissues are to cancer treatmentMetabolites called nucleotides are the building blocks of DNA and can impact cancer's sensitivity or resistance to chemotherapy and radiation in brain cancer., show how a specific nucleotide metabolite, called GTP, controls responses to radiation and chemotherapy in an unexpected way.
Researchers previously thought that this only happened because nucleotides are the building blocks that form DNA. But these findings uncover an entirely new way that nucleotides control DNA repair. What's more, Wahl and collaborator Weihua Zhou, Ph.D., found this to be true for normal tissue in addition to cancer cells."It's a generalizable finding," said Zhou, research assistant professor of radiation oncology and first author of the study.
Wahl says these findings are fundamental biologic discovery that translates into clinical applications for this trial and potential future trials.The discovery that GTP acts as a signaler helps explain the biological underpinnings of why focusing on GTP is a worthwhile pursuit and could help researchers figure out which patients will derive the most benefit from GTP modulators in the clinical trial.
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