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Researchers at Mayo Clinic have established new criteria for diagnosing a memory-loss syndrome in older adults, known as Limbic-predominant Amnestic Neurodegenerative Syndrome , which impacts the brain’s limbic system and is often mistaken for Alzheimer’s disease. These criteria provide a framework for more precise diagnosis and treatment, offering hope for better management of symptoms and tailored therapies for patients.
“In our clinical work, we see patients whose memory symptoms appear to mimic Alzheimer’s disease, but when you look at their brain imaging or biomarkers, it’s clear they don’t have Alzheimer’s. Until now, there has not been a specific medical diagnosis to point to, but now we can offer them some answers,” Jones says. “This research creates a precise framework that other medical professionals can use to care for their patients.
Without signs of Alzheimer’s disease, the researchers looked at the involvement of one possible culprit – a buildup of a protein called TDP-43 in the limbic system that scientists have found in the autopsied brain tissue of older adults. Researchers have classified the build-up of these protein deposits as. These protein deposits could be associated with the newly defined memory loss syndrome, but there are also other likely causes and more research is needed, the authors say.
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