Matcha Tea Powder’s Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress

A closer look at Matcha tea powder's antidepressant-like effects kumamotou_int

-test). This suggests that Matcha tea powder ameliorates the depression states and slightly improves the anxiety levels in C57BL/6J mice.Depression is the most-prevalent mental disorder in the world, and with changing social systems, the number of patients is expected to continue to increase. In the present study, we hypothesized that Matcha tea, a traditional Japanese drink, could improve depression levels, and we evaluated it by the tail suspension test in mice.

Here, we compared the Matcha tea powder’s effects on mice in different mental states and found that Matcha tea powder exerted its antidepressant-like effect only in C57BL/6J mice under high mental stress due to social isolation. C57BL/6J and BALB/c mice have been reported to have different stress responses [], and we revealed that the activation states of the PFC and NAc regions in C57BL/6J mice were lower than those of BALB/c mice.

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