A study published in AlzheimersRes finds that using the drug masitinib as an adjunct to cholinesterase inhibitor and/or memantine may benefit patients with mild-to-moderate Alzheimer’s disease.
Study AB09004 was conducted according to the Declaration of Helsinki, Good Clinical Practice guidelines, and national regulations. An independent data monitoring committee periodically reviewed blinded patient safety and efficacy data. The trial protocol was approved by the appropriate Independent Ethics Committee/Institutional Review Board of all participating sites and all subjects provided informed consent.Masitinib is under clinical development by the study funder, AB Science.
Summary of most frequent severe adverse events for masitinib cohorts relative to pooled placebo cohort over the 24-week treatment period and corresponding incidence rate ratios .Summary of most frequent non-fatal serious adverse events for masitinib cohorts relative to pooled placebo cohort over the 24-week treatment period and corresponding incidence rate ratios .Additional pooled placebo sensitivity analysis for the titrated masitinib 6.0 mg/kg/day parallel group .
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