Latest March Madness odds for every Round 1 matchup on March 20 and March 21, 2025.
The latest odds for every March Madness Round 1 matchup — from the biggest favorites to the teams on upset alert.Photo By - Imagn Images. St. John's Red Storm guard Kadary Richmond brings the ball up court during the Big East Tournament.We've got the latest odds for each of those 32 matchups, with no shortage of intrigue for potential Cinderellas, teams looking to turn First Four wins into deep tournament runs, and favorites looking to take care of business.
The final session for Round 1 is highlighted by defending champion UConn facing Oklahoma, plus blue bloods in Florida, Michigan State, and Kentucky playing — plus Arizona, which is the biggest upset alert game vs. Akron.: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
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