The monoclonal antibody in development as maintenance therapy for people with moderately to severely active ulcerative colitis was more effective than placebo.
The primary outcome of clinical remission at 44 weeks was greater with either of two dose regimens of guselkumab than with placebo, David Rubin, MD, reported as part of his presentation here at
Targeting both the IL-23 circulating in the tissue and the receptor remains to be proven,"but nonetheless seems reasonable," he said. Participants had a mean age of 41 years and a mean disease duration of 7.8 years. The 40% using oral corticosteroids were tapered off during the study. Among the participants who achieved clinical remission, 69% of them also showed complete remission on endoscopy.
"As we get more data from these more selective interleukins, we'll get a better sense of how that plays out" vs other similar agents in development, he added.One or more adverse events were reported by 70% of the higher-dose guselkumab group, 65% of the lower-dose guselkumab group, and 68% of the placebo group.
Ulcerative Colitis (UC) UC - Ulcerative Colitis Remission Inflammatory Bowel Disease IBD - Inflammatory Bowel Disease IBD Biologic Therapy Biologics Colitis Interleukins Psoriatic Arthritis Arthropathic Psoriasis Psoriatic Arthropathy Psa Corticosteroid Taper Stroke Cerebrovascular Accident CVA - Cerebrovascular Accident Corticosteroid Monoclonal Antibody
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Lawsuit alleges negligence in hiring of maintenance man accused of torturing residentA lawsuit has been filed accusing a property owner and management company of negligent hiring practices after a maintenance worker for a Baltimore apartment building allegedly raped and tortured one of the residents.
Read more »
Lawsuit alleges negligence in hiring of maintenance man accused of torturing residentBALTIMORE (AP) — April Hurley’s attacker entered her apartment after identifying himself as the building maintenance man — a job he should never have
Read more »
Cognitive factors may influence attrition, weight loss, and weight maintenance.Specific cognitive factors are associated with attrition, weight loss, and maintenance, but are not usually addressed by the treatment of obesity
Read more »
Maintenance routine sought for Oceanside's Loma Alta CreekConsultant would develop plan and obtain permits for regular removal of cobblestone berm that builds up on the beach
Read more »
Teslas Have Cheapest 10-Year Maintenance Costs: Consumer ReportsThe car brands with the cheapest maintenance costs include Tesla, Buick and Toyota.
Read more »
KTYC: 22-year-old maintenance worker dies after being hit by van during construction projectMakayla Garcia, 12, was last seen near her downtown home on April 17.
Read more »