Kansas City (1-1) is expected to be among the NFL's best teams again this year, while Arizona (1-1) is a popular pick to be among the worst.
Franchise quarterback Kyler Murray is likely out for the first several weeks of the season while he recovers from a torn ACL suffered last year.
The Chiefs built a 17-0 lead by late in the second quarter following Harrison Butker's 28-yard field goal. The Cardinals cut it to 17-7 just before halftime on Keaontay Ingram's 5-yard touchdown. Kansas City's backup quarterbacks both had strong performances. Shane Buechele was 10 of 10 for 105 yards, while also running for a 15-yard touchdown. Blaine Gabbert was 7 of 8 for 120 yards and two touchdowns.
The Chiefs' four quarterbacks — Mahomes, Buechele, Gabbert and fourth-stringer Chris Oladokun — combined to complete 31 of 38 passes for 393 yards and three touchdowns.
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