The compound in psychedelic mushrooms helped heavy drinkers cut back or quit entirely in the most rigorous test of psilocybin for alcoholism
The new research, published Wednesday in JAMA Psychiatry, is “the first modern, rigorous, controlled trial" of whether it can also help people struggling with alcohol, said Fred Barrett, a Johns Hopkins University neuroscientist who wasn't involved in the study.
While it’s not known exactly how psilocybin works in the brain, researchers believe it increases connections and, at least temporarily, changes the way the brain organizes itself. Before enrolling in the study in 2018, Orr had five or six drinks every evening and more on weekends. “It made alcohol irrelevant and uninteresting to me,” Orr said. Now, “I am tethered to my children and my loved ones in a way that just precludes the desire to be alone with alcohol."
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