Specialists fiercely debated best strategies for treating advanced lymphoma but could not reach consensus.
NEW YORK — In a three-way debate on whether to prioritize chimeric antigen receptor T-cell therapy, bispecific antibodies , or one of the novel oral targeted therapies for relapsed/refractory
“The majority of these patients are being managed in the community,” Rhodes argued at the 2024 Lymphoma, Leukemia, &Congress. Access to tertiary centers where the most advanced therapies are available in some cases might not even be feasible. “The biggest advantage is that these therapies…are off the shelf,” she said. This avoids the delay of T-cell manufacturing, the potential need for bridging therapies, and the need for conditioning regimens. With more experience, BsAbs offer the potential for treatment even in a community-practice setting, particularly for maintenance dosing.
In particular, he would not rule out CAR T-cell therapy in patients with comorbidities or other characteristics that raise questions about fitness for aggressive treatment. “Do you stop what is already working?” Landsburg asked rhetorically, suggesting that the best way forward is not always clear.. The entry criteria and design of the three pivotal trials differed, so their specific indications vary. Looking across the trials, Landsburg suggested that there might be differences in activity as defined by objective response rates or risk for cytokine release syndrome, but these remain theoretical without head-to-head comparisons.
Non-Hodgkin Lymphoma NHL Biologic Therapy Biologics Chimeric Antigen Receptor T-Cell Therapy Chimeric Antigen Receptors Chimeric Immunoreceptors Chimeric T-Cell Receptors Artificial T-Cell Receptors CAR T Chimaeric Antigen Receptor T-Cell Therapy Chimaeric Antigen Receptors Chimaeric Immunoreceptors Chimaeric T-Cell Receptors Lymphoma Malignant Lymphoma
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