'Tumor behavior upon recurrence is often more aggressive, and patients may quickly exhaust safe and effective options for surgery and radiation.'
WASHINGTON — A phase 2 study has demonstrated encouraging results for lutetium-177 dotatate in patients with surgery- and radiation-refractory meningioma.
Participants received 177Lu-dotatate at a dose of 7.4 GBq every 8 weeks for a total of four administrations. The primary endpoint was progression-free survival at 6 months, with a historical benchmark of 26% established by the Response Assessment in Neuro-Oncology working group. The 1-year overall survival rate was 88.9% , and the 2-year OS rate was 63.8% . The median OS was 27.8 months. Notably, five patients remained progression free at the time of reporting, with one patient maintaining stability for 3.5 years post-enrollment.The treatment demonstrated a manageable safety profile, and no grade 4 or 5 adverse events attributable to treatment were reported.
While 177Lu-dotatate shows promise, Merrell cautioned against considering it as a first-line treatment at this stage.
Head And Neck Cancer Head And Neck Cancer (HNC) Meningioma Brain Meningioma Surgery Tumor Brain Tumor Brain Tumour Refractory Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial
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