Late breaker data presented at the annual meeting of the American Academy of Dermatology reveals that some patients with alopecia areata (AA) experience slow hair regrowth, complicating the decision of when to stop JAK inhibitors due to inadequate response. Despite disappointing early results, many patients catch up and achieve complete hair regrowth after several years of treatment.
SAN DIEGO — In patients with alopecia areata , the decision of when to give up on JAK inhibitors because of an inadequate response is being complicated by long-term follow-up showing that some patients accrue hair very slowly, according to late breaker data presented at the annual meeting of the American Academy of Dermatology.
In the as-observed responses over time, the trajectory of response continued to climb through 76 weeks of follow-up in all three groups. Basically,"those with a SALT score of 94 did just as well as those with a SALT score of 51 when followed long-term," he said, noting that this was among several findings that confounded expectations.
To clarify this observation, Dr Sinclair made an analogy between acute and chronic urticaria. Chronicity appears to change the pathophysiology of both urticaria and AA, making durable remissions more difficult to achieve if the inflammatory response was persistently upregulated, he said. In the context of late breaking 68-week data with deuruxolitinib, an oral JAK inhibitor currently under FDA review for treating moderate to severe AA, presented in the same AAD session as Dr Sinclair's baricitinib data,, associate professor of dermatology, Yale University, New Haven, Connecticut, described similar long-term response curves. At 24 weeks, the SALT ≤ 20 response was achieved in 34.9% of patients, but climbed to 62.8% with continuous therapy over 68 weeks.
Alopecia Areata JAK Inhibitors Hair Regrowth American Academy Of Dermatology Late Breaker Data
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Big third inning propels Houston Academy past Northside Methodist AcademyAlready winners this season, William Byron and Kyle Larson are the favorites to find Victory Lane at the one-mile track
Read more »
Doris Kearns Goodwin, Laurie Anderson to be honored by American Academy of Arts & LettersDoris Kearns Goodwin, Laurie Anderson and the president of the Harlem School of the Arts, are being honored by the American Academy of Arts and Letters.
Read more »
Doris Kearn Goodwin and Laurie Anderson to receive medals from American Academy of Arts and Letters |Doris Kearns Goodwin, Laurie Anderson and the president of the Harlem School of the Arts, James C. Horton, are being honored by the American Academy of Arts
Read more »
Doris Kearn Goodwin and Laurie Anderson to receive medals from American Academy of Arts and LettersDoris Kearns Goodwin, Laurie Anderson and the president of the Harlem School of the Arts, James C.
Read more »
Doris Kearn Goodwin and Laurie Anderson to receive medals from American Academy of Arts and LettersDoris Kearns Goodwin, Laurie Anderson and the president of the Harlem School of the Arts, James C. Horton, are being honored by the American Academy of Arts and Letters. Goodwin, the Pulitzer Prize winning historian, is receiving a Gold Medal for biography. Anderson, the avant-garde performer, will be given a Gold Medal for music.
Read more »
Doris Kearn Goodwin and Laurie Anderson to receive medals from American Academy of Arts and LettersDoris Kearns Goodwin, Laurie Anderson and the president of the Harlem School of the Arts, James C.
Read more »