Dupilumab maintained its effectiveness in patients with atopic dermatitis for up to 5 years, with adverse events and ineffectiveness being the primary reasons for discontinuation, in a cohort study reflecting daily practice.
Dupilumab remained effective in most patients with atopic dermatitis up to 5 years, although nearly a quarter of patients in the cohort study discontinued treatment because of adverse events and/or ineffectiveness, researchers report.A prospective multicenter cohort study evaluated 1286 patients with AD from the BioDay registry in the Netherlands treated with dupilumab between October 2017 and December 2022.
The median follow-up time was 87.5 weeks; patients were seen at baseline, 4 weeks, and then every 3-6 months. Most patients achieved an EASI score ≤ 7 at 16 weeks, as did 12 of the 17 patients evaluated at 5 years. After 16 weeks, 71.2% of patients achieved NRS scores for pruritus ≤ 4, as did 15 of the 17 evaluated at 5 years.
Atopic Dermatitis Atopic Eczema Pruritus Pruritis Itch Children Child Childhood Pediatrics Kids Chemokines Eosinophils Eosinophil Granulocytes Thymic Artificial Intelligence Deep Learning AI NPL Machine Learning ML Natural Language Processing Artificial Neural Networks Eczema Geriatrics Elder Care Geriatric Medicine Older Adults Seniors Senior Citizens Elderly
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