Long-course RT for rectalcancer is more likely to spare organs than short-course therapy, including when chemotherapy is provided first as part of a TNT strategy, shows new research. GITwitter OncTwitter
is more likely to spare organs than short-course therapy, including when chemotherapy is provided first as part of a total neoadjuvant therapy strategy, shows new research presented at the ASCO Gastrointestinal Cancers Symposium 2023.
Long-course and short-course radiation have similar outcomes in terms of patients going on to need surgery, but it’s not clear which is superior in terms of organ sparing, toxicity, and side effects, said Paul Romesser, MD, a radiation oncologist with Memorial Sloan Kettering Cancer Center, New York, who served as first author of the study.
Why might long-course therapy be better? “It’s probably just coming down to the biologically equivalent dose,” which is likely lower in short-course radiation, Dr. Romesser said.a previous report
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