Starting treatment for AUD with extended-release naltrexone injections in the ED produced a dramatic reduction in alcohol consumption, according to findings presented at the ACEP22.
, professor of emergency medicine at UCSF."Right now, we do very little for people who come to the ED with AUD, so it is a missed opportunity to intervene, especially given the volume of visits we see and that our patient population is one that often has significant barriers to accessing outpatient treatment."
Twenty-five of the 32 participants completed all their study visits, and 22 continued taking naltrexone after the 12 weeks. "The median alcohol consumption when measured over the last 2 weeks of the study was zero," Raven said."This doesn't mean everyone was at zero, but this was the median and reflects that many participants stopped drinking altogether. We were pleasantly surprised by this. I don't know that we thought so many people who participated would actually fully abstain."
Raven said she hoped more would enroll but that"a number of people actually did not want the injection or were not ready to think about stopping." Still, she said, the 18% enrollment is"a major improvement," considering that no attempt was made to initiate treatment with naltrexone prior to the study. Oral naltrexone, rather than the injection, could be offered to improve participation, but oral naltrexone has to be taken daily, she said.
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