Location, Location, Location: It Matters for Gut Health Too

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Location, Location, Location: It Matters for Gut Health Too
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Recent research into the gut microbiome has highlighted the interdependence of the ecosystems within human bodies and the ecosystems that surround them. So how can physicians take the ecosystem into consideration? GastroTwitter

On the roof of a seven-story apartment building, Rupa Marya, MD, squats to weed a bed of chard. Tall herbs flower against the backdrop of office buildings, shipping cranes, and commuter trains.It's a Monday afternoon at the 1-acre Rooftop Medicine Farm. Most of Marya's colleagues at the University of California, San Francisco , where she works as a hospitalist, are checking on patients in antiseptic rooms and tapping reports under fluorescent lights.

"In newly industrialized countries like India, China, and Brazil, we're starting to see the incidence of IBD just skyrocket," Kaplan says.and breastmilk as babies, through contact with soil, and through living in close contact with farm animals and people in large households. Our diets lack nutrients, such as soluble fiber, to feed these organisms. Pollution, antibiotics, and tobacco kill some of those that remain.

"Depending upon the specific kind of microbes you carry in your gut, you may experience an exposure physiologically differently than I do," says Thomas Sharpton, PhD, associate professor of microbiology and statistics at Oregon State University."There are some gut microorganisms that can put us into a shields-up state that ramp up inflammatory responses," Sharpton says.

Sharpton and his colleagues are putting powerful computers to work sequencing the genomes of the complex communities of organisms in the human gut as well as all the chemicals found there. One goal is to predict how an individual might respond to a particular toxin or infection. Not only do the Rooftop Medicine Farm and Te Kwe A'naa Warep follow organic practices but they employ indigenous ecologic techniques with the goal of greater biodiversity, improved water retention, and carbon dioxide stabilization in the soil, along with better relationships between indigenous and nonindigenous people.

"We have the privilege to be at the bedside, and to witness how these dysfunctional social systems are impacting the bodies of people," Marya says."And we have a duty to speak up about it."

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