A typical UK household will now pay no more than £2,500 a year on their energy bill for the next two years, from October 1.
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Parked Fiat 500 written off in hit and runA couple are asking for help after they found their parked car written off by a hit and run.
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'How will I pay?' Preston chippy boss faces a 500 percent energy bill increaseA Preston fish and chip shop operator says he is facing an impossible-to-swallow increase in his energy costs - and is urging the government to act before businesses like his are choked by unaffordable bills.
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Idyllic hotel offers unique business opportunity on NC500 as it goes up for saleThe stunning Highland hotel is found in the beautiful coastal village of Lybster on the famous North Coast 500 route.
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Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma - Journal of Hematology & OncologyMultiple myeloma (MM) and its precursors monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) are 2–3 times more common in African Americans (AA) than European Americans (EA). Although epigenetic changes are well recognized in the context of myeloma cell biology, the contribution of 5-hydroxymethylcytosines (5hmC) to racial disparities in MM is unknown. Using the 5hmC-Seal and next-generation sequencing, we profiled genome-wide 5hmC in circulating cell-free DNA (cfDNA) from 342 newly diagnosed patients with MM (n = 294), SMM (n = 18), and MGUS (n = 30). We compared differential 5hmC modifications between MM and its precursors among 227 EA and 115 AA patients. The captured 5hmC modifications in cfDNA were found to be enriched in B-cell and T-cell-derived histone modifications marking enhancers. Of the top 500 gene bodies with differential 5hmC levels between MM and SMM/MGUS, the majority (94.8%) were distinct between EA and AA and enriched with population-specific pathways, including amino acid metabolism in AA and mainly cancer-related signaling pathways in EA. These findings improved our understanding of the epigenetic contribution to racial disparities in MM and suggest epigenetic pathways that could be exploited as novel preventive strategies in high-risk populations.
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Liz Truss to announce major plan on energy billsLiz Truss will announce a major plan on energy bills tomorrow. PGMcNamara explains what consumers and businesses can expect.
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