The race for coronavirus treatments and vaccines is heating up. Here are the 12 most important events to watch for in June, from fresh vaccine data to new antibody drug trials.
The race for coronavirus treatments and vaccines is expected to maintain its frenetic pace in June. Business Insider identified the 12 top events to watch for this month, including new drugs and vaccines starting human testing and a range of data readouts from ongoing studies.
The catalysts will impact drug companies ranging in size from massive to tiny, including biopharma giants like Eli Lilly and Regeneron and small biotechs like NantKwest and Inovio Pharmaceuticals.June is shaping up to be a critical month for several coronavirus treatment and vaccine research programs. Some will start human testing for the first time, while others will wrap up and report results from clinical trials. There's no shortage of activity in hunting for pharmaceutical solutions to COVID-19, the disease caused by the novel coronavirus. The World Health Organization has tallied 125 coronavirus vaccine programs. Several hundred experimental drugs are being looked at to treat infected people. Roughly 40 treatments are now in human testing, according to Informa Pharma Intelligence. Here are the 12 top catalysts expected to happen in June in the race for coronavirus treatments and vaccines.The New York biotech Regeneron and the French pharmaceutical company Sanofi are testing their arthritis drug called Kevzara in critically ill COVID-19 patients. Kevzara blocks a type of cytokine called IL-6, which the human immune system produces and can promote inflammation. Severe COVID-19 cases have been marked by an overwhelming immune response and high levels of inflammation. Researchers are now testing to see if IL-6 blockers like Kevzara can tamp down a runaway immune response.to just the sickest of patients after a data review. Results from this trial, which randomly tested Kevzara against a group receiving a placebo, are due in June. It will be the first high-quality evidence to suggest whether or not the IL-6 theory can help the sickest of COVID-19 patients. Separately, University of Minnesota researchers are set to soon publish their research from a trial testing whether hydroxychloroquine can protect people from the coronavirus. The malaria pills were given as a post-exposure prophylaxis treatment, meaning after someone had been exposed to the virus but before they had developed symptoms. Several studies have demonstrated that hydroxychloroquine doesn't work in COVID-19 patients who are already sick enough to be in the hospital. But supporters of the drug say it has to be used very early and can help prevent the disease. There's no high-quality evidence that supports this hypothesis, but the Minnesota trial will likely provide an answer.There are already 10 vaccine candidates now in the clinic. At least four more programs are aiming to join them in June. All of these vaccine candidates will start in small-scale studies primarily focused on safety. Researchers will also test volunteers to see if the vaccine provoke an immune response, although additional trials with more people will be needed to tell if any immune responses actually protect people from the virus. The German biotech CureVac with a messenger RNA vaccine Biotech billionaire Patrick Soon-Shiong's companies NantKwest and ImmunityBio with an adenovirus-based vaccine The UK government has backed an mRNA vaccine developed by Imperial College London, which is set to start a human safety study A tiny British biotech called Stabilitech Biopharma says it is ready to start testing an oral vaccine pill in humansThere are more than 25 coronavirus vaccines set to be tested in people this year. Here are the 10 leading vaccine candidates, and what to watch for in the rest of 2020.While those programs enter the clinic, several other vaccines will start to report out results from early human trials. The first vaccine programs already gave a taste of preliminary data in May. The upstart biotech Moderna
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