Liraglutide is the first GLP-1 agonist to show benefit in this age group and could provide young patients a much-needed option.
After a year of treatment, children who received daily liraglutide injections had a 5.8% reduction in body mass index , while those receiving placebo experienced a 1.6% increase in BMI . Almost half of the children who received liraglutide had at least a 5% reduction in BMI .
However, because body composition was not measured,"the possibility of a loss of muscle mass, at least initially, cannot be excluded," write Timothy Barrett, MBBS, PhD, and Julian Hamilton-Shield, MBChB, MD, of the College of Medicine and Health at the University of Birmingham and Bristol Medical School at the University of Bristol, UK, in anEven so, the editorialists acknowledge that"the reduction in the BMI standard-deviation score of 0.
In addition, those taking liraglutide had reductions in systolic and diastolic blood pressure of 1.7 mm Hg and 1.2-mm Hg, respectively, and about a 0.2% decrease in A1c, Fox reported. Forty-five of the 56 children who received liraglutide had gastrointestinal adverse events, which occurred mainly during the dose-escalation phase of the study, said Fox. Three serious adverse events thought to be drug-related included two cases of vomiting and one ofBoth Fox and Vaidya noted that daily injections could be challenging for children, especially the youngest.
"Despite the need for further studies, the results of the trial reported by Fox et al. provide much-needed evidence for the effects of a GLP-1 receptor agonist in young children with obesity, offering a therapeutic option in prepubertal children with severe obesity as an adjunct to healthy lifestyle interventions," write Barrett and Hamilton-Shield.
Obesity In Children Pediatric Obesity Paediatric Obesity Children Child Childhood Pediatrics Kids Obesity Obese Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Body Mass Index BMI GLP-1 Receptor Agonists Glucagon-Like Peptide-1 Receptor Agonists Adolescent Medicine Teens Teenage Teenager Adolescent Health Adolescents
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