A new screening test raises the possibility of catching pancreatic cancer earlier, when tumors can be removed, and patients cured.
Goel and colleagues developed a signature for pancreatic cancer based on microRNAs identified in the exomes shed from pancreatic cancer s and cell-free DNA markers found in the blood of patients with the disease.
In both the initial and validation tests, the microRNA assay had an accuracy of about 90% for stage I/II pancreatic cancer, already far better than commercially available assays. "As a GI oncologist, I know how lethal and hard to treat pancreatic cancer is," he said. A test that could reliably detect pancreatic cancer early, with an acceptable false-positive rate, would be extremely useful.
The idea is to find the earliest possible signs of this disease to see if we can find it not"at the moment of clinical diagnosis, but possibly 6 months, 1 year, 2 years earlier" than with radiologic imaging, Goel said.
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